The advanced research teams of Silab Softcare have developed a 3D in vitro model of reconstructed epidermis that mimics acneic skin. The characterization of this model has just been published in the scientific journal Experimental Dermatology [1]. This new screening tool allowed the group to demonstrate the properties of Acnesium, its latest naturally-derived active ingredient for the daily care of acneic skins.
Most 3D models mimicking acneic skin do not take into account all of the four main components of this skin inflammation: hyper-seborrhea combined with a modification of the composition of sebum, colonization by Cutibacterium (C.) acnes, in particular the virulent phylotype IA1, hyperkeratinization and a secreted inflammation.
Multifactorial model
“Most 3D models mimicking acneic skin independently use hyperseborrhea or invasion by C. acnes to induce the characteristics of acneic skin,” said Silab. However, as these two factors are inter-related at the early stages of the pathology, the French manufacturer of cosmetic active ingredients sought to develop a 3D model combining sebum alteration and invasion by C. acnes.
Published by Vincent Gallon on February 12th, 2021
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