Alternative Methods Accepted by US Agencies via National Toxicology Program

15 September 2020

The table below includes:

  • Methods for chemical safety testing that are accepted by U.S. and international regulatory authorities as replacement, reduction, or refinement alternatives to required animal tests
  • Guidances to support replacement, reduction, or refinement alternatives to animal use for required testing: these documents are recommendations that do not necessarily establish legally enforceable responsibilities

An overview of non-animal methods that have been proposed for regulatory safety or efficacy testing of chemicals or biological agents can be found in the Tracking System for Alternative Methods (TSAR) resource, provided by the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM). TSAR tracks progress of an alternative method from submission for validation through to its final adoption by inclusion into the regulatory framework

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Published via National Toxicology Program


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